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KMID : 1134820140430060807
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 6 p.807 ~ p.813
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Protective Effects of Radiation-induced Blackberry Mutant Extract on Carbon Tetrachloride (CCl4)-induced Liver Injury in Sprague-Dawley Rats
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Cho Byoung-Ok
Lee Chang-Wook
So Yang-kang
Jin Chang-Hyun
Yook Hong-Sun
Byun Myung-Woo
Jeong Yong-Wook
Park Jong-Chun
Jeong Il-Yun
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Abstract
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The objective of the present study was to investigate the protective effects of anthocyanin-enriched extract from radiation-induced blackberry (Rubus fruticosus L.) mutant (γ-B201) against carbon tetrachloride (CCl4)-induced liver injury in Spargue-Dawley (SD) rats. The in vivo results show that γ-B201 attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in CCl4-treated SD rats. Histopathological examination of rat livers showed that γ-B201 reduced the incidence of liver lesions induced by CCl4. Moreover, γ-B201 prevented DNA damage in CCl4-treated SD rats. Furthermore, administration of γ-B201 significantly increased the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), in CCl4-treated rat livers. In conclusion, the present study suggests that γ-B201 blackberry extract protects the liver from CCl4-induced hepatic damage through an antioxidant mechanism. Therefore, γ-B201 blackberry may be functional food material for human health.
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KEYWORD
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blackberry, carbon tetrachloride, lipid peroxidation, DNA damage, antioxidant enzyme
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